A serial killer using an author's work for inspiration is hardly a groundbreaking concept, but I'm intrigued by the Poe angle. A while back, there was an Edgar Allan Poe TV series that never came to fruition. John Cusack is a great choice for the lead. It looks pretty tame when you compare it to the upcoming Abraham Lincoln: Vampire Hunter and FDR vs. Werewolves projects -- and no, I'm not joking.
I'm not one to chase trends, but scripts about historical figures involved in crazy adventures sure seem to get a decent amount of attention these days. At the very least, they could make for a decent writing sample.